Title of article
Microwave-assisted solid phase synthesis of Imatinib, a blockbuster anticancer drug
Author/Authors
Leonetti، نويسنده , , Francesco and Capaldi، نويسنده , , Carmelida and Carotti، نويسنده , , Angelo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
3455
To page
3458
Abstract
An expeditious, high yield and convenient synthesis of Imatinib was carried out on an aldehydic, super acid-sensitive resin, through an efficient, microwave-assisted synthetic protocol. The high versatility of the reaction scheme may enable the straightforward preparation of libraries of potential protein kinase inhibitors endowed with large molecular diversity.
Keywords
microwave heating , Imatinib , Chronic myeloid leukaemia , Gleevec , Solid phase synthesis
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1854949
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