Author/Authors :
Fujimura، نويسنده , , Takashi and Yonekura، نويسنده , , Syuji and Horiguchi، نويسنده , , Shigetoshi and Taniguchi، نويسنده , , Yuriko and Saito، نويسنده , , Akemi and Yasueda، نويسنده , , Hiroshi and Inamine، نويسنده , , Ayako and Nakayama، نويسنده , , Toshinori and Takemori، نويسنده , , Toshitada and Taniguchi، نويسنده , , Masaru and Sakaguchi، نويسنده , , Masahiro and Okamoto، نويسنده , , Yoshi، نويسنده ,
Abstract :
The aims of this study were to examine the therapeutic effects of sublingual immunotherapy (SLIT) and to identify potential biomarkers that would predict the therapeutic response in a randomized, double-blind, placebo-controlled clinical trial. The trial was carried out over two pollinosis seasons in 2007 and 2008. Carry-over therapeutic effects were analyzed in 2009. SLIT significantly ameliorated the symptoms of pollinosis during the 2008 and 2009 pollen seasons. Cry j 1-specific cytokine production in a subgroup of patients with mild disease in the SLIT group was significantly attenuated. The ratio of specific IgE to total IgE before treatment correlated with the symptom-medication score in the SLIT group in 2008. Patients with increased Cry j 1-iTreg in the SLIT group had significantly improved QOL and QOL-symptom scores. In summary, the specific IgE to total IgE ratio and upregulation of Cry j 1-iTreg are candidates for biomarker of the clinical response to SLIT.
Keywords :
Sublingual immunotherapy , immunotherapy , Regulatory T cell , allergic rhinitis , Biomarker , Japanese cedar pollinosis
