Title of article :
A variation of Mattox rearrangement mechanism under alkaline condition
Author/Authors :
Li، نويسنده , , Min and Chen، نويسنده , , Bin and Lin، نويسنده , , Mingxiang and Chan، نويسنده , , Tze-Ming and Fu، نويسنده , , Xiaoyong and Rustum، نويسنده , , Abu، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2007
Abstract :
A variation of the Mattox rearrangement, a key degradation pathway under acidic conditions for corticosteroids possessing the 1,3-dihydroxyacetone side chain, has been found to occur for the 17,21-diesters of these corticosteroids but under the alkaline condition. The mechanism of this variation of the original Mattox rearrangement is proposed.
Keywords :
Corticosteroids , Mattox rearrangement , Betamethasone dipropionate , Degradation , Betamethasone enol aldehyde
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
