Title of article
Effect of the leaving group on the reaction of 2-aminopyrroles with electron deficient heteroaromatic azadienes: substitution by addition–elimination versus cycloaddition
Author/Authors
De Rosa، نويسنده , , Michael and Arnold، نويسنده , , David and Medved’، نويسنده , , Miroslav، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
3991
To page
3994
Abstract
When a good leaving group is present in the heteroaromatic azadiene, reaction with 2-aminopyrroles occurs by substitution by addition–elimination instead of cycloaddition. This novel reaction is sensitive to steric effects and takes place in 2-amino-1-methylpyrrole at C-5 and the exo amino group but at C-3 in 2-amino-1-t-butylpyrrole.
Keywords
2-Aminopyrroles , Substitution , Addition–elimination , Zwitterions , Ambident behaviour , Meisenheimer complex , Steric effects , Leaving group
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1855121
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