Author/Authors :
Tatsuta، نويسنده , , Kuniaki and Yamaguchi، نويسنده , , Takahiro and Tsuda، نويسنده , , Yusuke and Yamaguchi، نويسنده , , Yumiko and Hattori، نويسنده , , Nobutaka and Nagai، نويسنده , , Hiroshi and Hosokawa، نويسنده , , Seijiro، نويسنده ,
Abstract :
The first total synthesis and structural determination of YCM1008A, a Ca2+ signaling inhibitor, have been achieved. The N-methoxy pyrano-pyridone moiety was synthesized by successive O- and N-conjugate additions with diketoamide 15. The absolute structure was determined to be (2R,3R,4S,8′R)-configuration.
