Title of article
Stereoselective 5-exo-trig radical cyclization in the enantioselective synthesis of Pregabalin
Author/Authors
Rodrيguez، نويسنده , , Verَnica and Quintero، نويسنده , , Leticia and Sartillo-Piscil، نويسنده , , Fernando، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
4305
To page
4308
Abstract
A practical stereoselective 5-exo-trig radical cyclization procedure was developed in order to prepare enantiomerically pure GABA derivative precursors (4-alkyl-pyrrolidin-2-ones). This procedure allows much more rapid access to optically pure GABA derivatives, such as the powerful antiepileptic agent (S)-(+)-3-aminomethyl-5-methylhexanoic acid (Pregabaline).
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1855233
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