Title of article
An efficient synthesis of 2-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)morpholine: a potent M1 selective muscarinic agonist
Author/Authors
Sunil Kumar، نويسنده , , Y.C. and Sadashiva، نويسنده , , M.P. and Rangappa، نويسنده , , K.S.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
4565
To page
4568
Abstract
2-(1-Methyl-1,2,5,6-tetrahydropyridin-3-yl)morpholine is useful for synthesizing potent antimicrobials including the arecoline derivatives, phendimetrazine and polygonapholine and was synthesised in nine steps with an overall yield of 36%. Bromination of 3-acetylpyridine and dehydration of a diol with cyclization were pivotal to the success of the strategy.
Keywords
Arecoline , 2-Acetyl pyridine , C-Substituted morpholines
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1855366
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