Cyclic disulfides as functional mimics of the histone deacetylase inhibitor FK-228
Author/Authors :
Mays، نويسنده , , Jared R. and Restituyo، نويسنده , , José A. and Katzenberger، نويسنده , , Rebeccah J. and Wassarman، نويسنده , , David A. and Rajski، نويسنده , , Scott R.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2007
Pages :
5
From page :
4579
To page :
4583
Abstract :
FK-228 is a potent histone deacetylase (HDAC) inhibitor with tremendous therapeutic potential against a wide array of human cancers. We describe the development of analogs that share FK-228’s novel mechanism of activation and HDAC inhibition.
