A highly efficient resolution protocol for 2′-halo-α-methylbenzylamines

A highly efficient resolution protocol for 2′-halo-α-methylbenzylamines is reported. Commercially available and inexpensive mandelic acid can be used for the resolution of the Br, Cl, and F derivatives to >99% de in a single crystallization. In addition, the reduction of acetophenone oximes using borane-dimethylsulfide is presented as a method for the preparation of racemic amine precursors.