Title of article
Asymmetric synthesis of (S)-(−)-N-acetylcolchinol via Ullmann biaryl coupling
Author/Authors
Broady، نويسنده , , Simon D. and Golden، نويسنده , , Michael D. and Leonard، نويسنده , , John and Muir، نويسنده , , James C. and Maudet، نويسنده , , Mickael، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
4627
To page
4630
Abstract
A modified Ziegler Ullmann coupling process has been developed as the key step in an effective synthesis of (S)-(−)-N-acetylcolchinol, analogues of which are selective vascular targeting agents with potential importance in cancer chemotherapy. Asymmetric induction is achieved by enamide hydrogenation using FerroTANE catalysts.
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1855402
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