Title of article :
Synthesis of a novel sphingosine kinase inhibitor (−)-F-12509A and determination of its absolute configuration
Author/Authors :
Maezawa، نويسنده , , Nobuhiro and Furuichi، نويسنده , , Noriyuki and Tsuchikawa، نويسنده , , Hiroshi and Katsumura، نويسنده , , Shigeo، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2007
Abstract :
The synthesis of a novel sphingosine kinase inhibitor, (−)-F-12509A ((−)-1), was achieved in a highly efficient manner that included nine longest linear steps and 45% overall yield from (−)-bicyclic β-ketoester (−)-2, and its absolute configuration was determined to be (5S,9S,10S).
Keywords :
Sphingosine kinase inhibitor , Dihydroxyquinone , Synthesis , absolute configuration
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
