Author/Authors :
Willand، نويسنده , , Nicolas and Folléas، نويسنده , , Benoit and Boutillon، نويسنده , , Christophe and Verbraeken، نويسنده , , Liesbeth and Gesquière، نويسنده , , Jean-Claude and Tartar، نويسنده , , André and Deprez، نويسنده , , Benoit، نويسنده ,
Abstract :
We describe a novel strategy for the synthesis of N-substituted nortropinone derivatives starting from tropinone. The key step of our synthesis is a reactivity umpolung of tropinone, which yields 8,8-dimethyl-3-oxo-8-azonia-bicyclo[3.2.1]octane iodide (IDABO) as a stable and convenient synthetic equivalent of cycloheptadienone.
Keywords :
Reactivity umpolung , one-step synthesis , Tropinone , Robinson synthesis
