Title of article :
Biological properties and regulation of IL-10 related cytokines and their contribution to autoimmune disease and tissue injury
Author/Authors :
Hofmann، نويسنده , , S.R. and Rِsen-Wolff، نويسنده , , A. and Tsokos، نويسنده , , G.C. and Hedrich، نويسنده , , C.M.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2012
Abstract :
The IL-10 cytokine family has nine members, four of which are located in the IL10 cluster on chromosome 1q32. These cytokines are the immune regulatory cytokine IL-10 itself, and the IL-20 subfamily members IL-19, IL-20, and IL-24. IL-10 instructs innate and adaptive immune responses and limits pro-inflammatory responses in order to prevent tissue damage. The IL-20 subfamily members are involved in host defense mechanisms, particularly from epithelial cells and seem essential for tissue integrity. Dysregulation of IL-10 family cytokines results in inflammation and autoimmune disease. Here, we discuss cellular source, gene regulation, and receptor complexes of cytokines in the IL10 cluster and their contribution to autoimmune disease and tissue damage.
Keywords :
Tissue injury , Autoimmune Disease , IL-10 , IL-19 , IL-20 , IL-24
Journal title :
Clinical Immunology
Journal title :
Clinical Immunology