Author/Authors :
Singh، نويسنده , , Sheo B. and Herath، نويسنده , , Kithsiri B. and Wang، نويسنده , , Jun and Tsou، نويسنده , , Nancy and Ball، نويسنده , , Richard G.، نويسنده ,
Abstract :
Platensimycin is a novel natural product antibiotic that inhibits bacterial growth by inhibiting fatty acid synthesis specifically inhibiting the elongation condensing enzyme FabF. Reaction with diazomethane at controlled temperatures led to selective methylation of the phenolic groups. Methylation, halogenation, reduction, epoxidation, Bayer–Villiger oxidation and details of the conversion of dihydroplatensimycin to the cyclic enamino-amido forms have been described.
