Title of article
Sequential ring-opening of trans-1,4-cyclohexadiene dioxide for an expedient modular approach to 6,7-disubstituted (±)-hexahydro-benzo[1,4]oxazin-3-ones
Author/Authors
Scheunemann، نويسنده , , Matthias and Sorger، نويسنده , , Dietlind and Kouznetsova، نويسنده , , Elena and Sabri، نويسنده , , Osama and Schliebs، نويسنده , , Reinhard and Wenzel، نويسنده , , Barbara and Steinbach، نويسنده , , Jِrg، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
5
From page
5497
To page
5501
Abstract
A modular approach to novel 6-amino-7-hydroxysubstituted hexahydro-benzo[1,4]oxazin-3-ones has been developed. The method involves a sequential ring-opening of trans-1,4-cyclohexadiene dioxide with amino nucleophiles. The resultant mono-epoxide from benzylamine was converted to a general electrophilic precursor, which enables the parallel treatment with amino nucleophiles to obtain a series of cyclohexane-fused morpholin-3-ones.
Keywords
Diepoxide , ring-opening , 4]oxazin-3-ones , VAChT
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1855854
Link To Document