Author/Authors :
Xiao، نويسنده , , Wei-Lie and Yang، نويسنده , , Liu-Meng and Li، نويسنده , , Li-Mei and Pu، نويسنده , , Jian-Xin and Huang، نويسنده , , Sheng-Xiong and Weng، نويسنده , , Zhi-Ying and Lei، نويسنده , , Chun and Liu، نويسنده , , Jingping and Wang، نويسنده , , Rui-Rui and Zheng، نويسنده , , Yongtang and Li، نويسنده , , Rong-Tao and Sun، نويسنده , , Han-Dong، نويسنده ,
Abstract :
Four novel highly oxygenated trinortriterpenoids, sphenalactones A–D (1–4), were isolated from the leaves and stems of Schisandra sphenanthera and their structures were elucidated by extensive analysis of 1D and 2D NMR data. Compounds 1–4 featured a C27 backbone and showed anti-HIV-1 activity with EC50 values in the range of 35.5–89.1 μg/mL with low cytotoxicity against C8166 cells (CC50 > 200 μg/mL).
Keywords :
Sphenalactones A–D , Schisandra sphenanthera , Trinortriterpenoid , Anti-HIV activity
