Author/Authors :
Andrade، نويسنده , , Regis M. and Hygino، نويسنده , , Joana and Kasahara، نويسنده , , Taissa M. and Vieira، نويسنده , , Morgana M. and Xavier، نويسنده , , Luciana F. and Blanco، نويسنده , , Bernardo and Damasco، نويسنده , , Paulo V. and Silva، نويسنده , , Rodrigo M. and Lima، نويسنده , , Dirce B. and Oliveira، نويسنده , , Ariane L. and Lemos، نويسنده , , Alberto S. and Andrade، نويسنده , , Arnald، نويسنده ,
Abstract :
This work aims to elucidate the effects of age and HIV-1 infection on the frequency and function of T cell subsets in response to HIV-specific and non-specific stimuli. As compared with the younger AIDS group, the frequencies of naive and central memory T cells were significantly lower in aged AIDS patients. Although there was also a dramatic loss of classical CD4+FoxP3+CD25+Treg cells in this patient group, high frequencies of IL-10-producing CD4+FoxP3− T cells were observed. In our system, the increased production of IL-10 in aged AIDS patients was mainly derived from Env-specific CD4+FoxP3−CD152+ T cells. Interestingly, while the blockade of IL-10 activity by monoclonal antibody clearly enhanced the release of IL-6 and IL-1β by Env-stimulated PBMC cultures from aged AIDS patients, this monoclonal antibody enhanced in vitro HIV-1-replication. In conclusion, HIV infection and aging undoubtedly contribute synergistically to a complex immune dysfunction in T cell compartment of HAART-treated older HIV-infected individuals.
Keywords :
CD152 , HIV , aging , Anti-retroviral therapy , IL-10 , FoxP3
