Title of article
Synthesis of (purin-6-yl)acetates and 6-(2-hydroxyethyl)purines via cross-couplings of 6-chloropurines with the Reformatsky reagent
Author/Authors
Hasn?k، نويسنده , , Zbyn?k and ?ilh?r، نويسنده , , Peter and Hocek، نويسنده , , Michal، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
5589
To page
5592
Abstract
A novel approach to the synthesis of 6-(2-hydroxyethyl)purines was developed based on Pd-catalyzed cross-coupling reactions of 6-chloropurines with the Reformatsky reagent followed by reduction by NaBH4 and treatment with MnO2. This methodology was successfully applied to the syntheses of 6-(ethoxycarbonylmethyl)- and 6-(hydroxyethyl)purine bases and nucleosides.
Keywords
purines , nucleosides , functionalized organometallics , Cross-coupling reactions
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1855902
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