Author/Authors :
Blanchet، نويسنده , , Jérôme and Pouliquen، نويسنده , , Mickael and Lasne، نويسنده , , Marie-Claire and Rouden، نويسنده , , Jacques، نويسنده ,
Abstract :
A short, reliable, and cheap synthesis of both enantiomers of β-proline, an efficient organocatalyst and an important building block in medicinal chemistry, has been developed in four steps (overall yield: 72%) from the diasteromeric adducts of methyl itaconate and (R)-α-methylbenzylamine. The key step involves the chemoselective reduction of a lactam group in the presence of a benzyl ester.
