Acuminatanol, the first 2′,2‴-bis-dihydrobiflavonol from the aqueous extract of Trichoscypha acuminata

One new 3′,4′,5′,5,7-pentahydroxy-2′,2‴-bis-dihydrobiflavonol, acuminatanol (1), was obtained from the aqueous extract of Trichoscypha acuminata. The structure elucidation process was performed primarily utilizing a capillary scale NMR probe. Acuminatanol (1) is the first example of a bis-dihydroflavonol linked exclusively via the B-rings at C-2′ and C-2‴ positions. To date, it is the first naturally-occurring compound reported from the genus Trichoscypha, and the first new natural product published from our compound libraries generated from the aqueous extracts of American and African plants.