Author/Authors :
Bisseret، نويسنده , , Philippe and Thielges، نويسنده , , Sabine and Bourg، نويسنده , , Stéphane and Miethke، نويسنده , , Marcus and Marahiel، نويسنده , , Mohamed A. and Eustache، نويسنده , , Jacques، نويسنده ,
Abstract :
We report the synthesis of an adenosyl-derived indolylphosphonamide analogue of salicyladenosylmonophosphate involved in the plague and tuberculosis siderophore biosyntheses. The compound proved to be a potent inhibitor of the Yersinia pestis salicylate adenylation domain YbtE catalyzing the initial step of yersiniabactin biosynthesis.
Keywords :
indole , Atherton–Todd reaction , Phosphonamidate , Plague , Yersiniabactin
