Title of article
Synthesis of a 2-indolylphosphonamide derivative with inhibitory activity against yersiniabactin biosynthesis
Author/Authors
Bisseret، نويسنده , , Philippe and Thielges، نويسنده , , Sabine and Bourg، نويسنده , , Stéphane and Miethke، نويسنده , , Marcus and Marahiel، نويسنده , , Mohamed A. and Eustache، نويسنده , , Jacques، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
6080
To page
6083
Abstract
We report the synthesis of an adenosyl-derived indolylphosphonamide analogue of salicyladenosylmonophosphate involved in the plague and tuberculosis siderophore biosyntheses. The compound proved to be a potent inhibitor of the Yersinia pestis salicylate adenylation domain YbtE catalyzing the initial step of yersiniabactin biosynthesis.
Keywords
indole , Atherton–Todd reaction , Phosphonamidate , Plague , Yersiniabactin
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1856171
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