Author/Authors :
Gonnot، نويسنده , , Vanessa and Tisserand، نويسنده , , Steve and Nicolas، نويسنده , , Marc and Baati، نويسنده , , Rachid and Mioskowski، نويسنده , , Charles، نويسنده ,
Abstract :
An efficient total synthesis of rhein and diacerhein has been accomplished by relying on a remarkable regioselective directed ortho metalation (DOM) followed by a one-pot two step addition-cyclization reaction, generating phthalide 5 intermediate efficiently.
Keywords :
Directed ortho metalation , anthraquinone , Rhein , Diacerhein
