Title of article :
Copper-free PdCl2/PPh3-catalyzed Sonogashira coupling reaction of aryl bromides with terminal alkynes in water
Author/Authors :
Guan، نويسنده , , Jin Tao and Weng، نويسنده , , Tan Qing and Yu، نويسنده , , Guang-ao and Liu، نويسنده , , Sheng Hua، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2007
Abstract :
A simple, copper-free and efficient catalytic system for the Sonogashira coupling reaction of aryl bromides with terminal alkynes in pure water has been developed. The use of PdCl2/PPh3 in the presence of pyrrolidine allows the coupling reaction to proceed at 120 °C in moderate to excellent yields.
Keywords :
water , copper-free , Aryl bromides , Sonogashira coupling reaction
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
