Author/Authors :
Ko، نويسنده , , Myoung Seok and Kim، نويسنده , , Hyo Jeong and Kim، نويسنده , , Hong Kyung and Yoon، نويسنده , , Nal Ae and Lee، نويسنده , , Unn Hwa and Lee، نويسنده , , Sang Chul and Chung، نويسنده , , Dae Kyun and Lee، نويسنده , , Byung Ju and Suh، نويسنده , , Jae Hee and Cho، نويسنده , , Wha Ja and Park، نويسنده , , Jeong Woo، نويسنده ,
Abstract :
Developmentally regulated GTP-binding protein 2 (DRG2) represents a novel subclass of GTP-binding proteins. We here report that transgenic overexpression of DRG2 in mice ameliorates experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). The protective effect of DRG2 in EAE was mediated by the inhibition of the development of TH17 cells. DRG2 enhanced the activity of PPARγ, which led to an inhibition of the nuclear factor kappa B (NF-κB) activity and IL-6 production in antigen presenting cells and an inhibition of the development of TH17 cells. Our results demonstrate that DRG2 is an essential modulator of EAE.
Keywords :
DRG2 , NF-?B , IL-6 , PPAR? , EAE , Th17
