Title of article
A new chemoenzymatic Baylis–Hillman approach for the synthesis of enantiomerically enriched umbelactones
Author/Authors
Kamal، نويسنده , , Ahmed and Krishnaji، نويسنده , , Tadiparthi and Venkat Reddy، نويسنده , , P.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
7232
To page
7235
Abstract
An efficient and convenient strategy for the enantioselective synthesis of enantiomerically enriched umbelactones is described utilizing a lipase-mediated resolution protocol, Baylis–Hillman reaction and ring closing metathesis as key steps. The lipase-resolution is carried out using several lipases from various sources in different solvents to afford the required intermediate 8 in good yield and high enantioselectivity.
Keywords
Lipase-resolution , ring-closing metathesis , Baylis–Hillman
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1856763
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