Title of article
The first total synthesis and structural determination of TMC-66
Author/Authors
Hosokawa، نويسنده , , Seijiro and Fumiyama، نويسنده , , Hitoshi and Fukuda، نويسنده , , Hisato and Fukuda، نويسنده , , Tomohiro and Seki، نويسنده , , Masashi and Tatsuta، نويسنده , , Kuniaki، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
7305
To page
7308
Abstract
The first total synthesis and structural determination of TMC-66, an ECE inhibitor, was achieved in short steps by efficient construction and coupling of segments. The oxidative coupling with phenols attaching to electron-withdrawing groups was realized with a novel copper(II) reagent.
Keywords
Structural determination , oxidative coupling , total synthesis , TMC-66 , ECE inhibitor
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1856802
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