Apply peptide C-terminal semicarbazides to peptide segment coupling using transfer active ester condensation technology

Peptide C-terminal semicarbazides are used as the starting materials in transfer active ester condensation technology to prepare HOCt active esters intermediates, which react with other peptide segments or reagents to afford long chain peptides, branch peptides and peptide C-terminal derivatives. The semicarbazido derivatives afford reliable results and avoid side reactions efficiently.