Title of article
The first expedient entry to the human melanogen 2-S-cysteinyldopa exploiting the anomalous regioselectivity of 3,4-dihydroxycinnamic acid–thiol conjugation
Author/Authors
Panzella، نويسنده , , Lucia and De Lucia، نويسنده , , Maria and Napolitano، نويسنده , , Alessandra and dʹIschia، نويسنده , , Marco، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
3
From page
7650
To page
7652
Abstract
The first convenient synthesis of 2-S-cysteinyl-3,4-dihydroxyphenylalanine (2-S-cysteinyldopa) in 30% overall yield is reported, which capitalizes on the anomalous regiochemistry of the oxidative coupling of 3,4-dihydroxycinnamic acid derivatives with thiol compounds, leading to 2-S rather than the usual 5-S conjugates.
Keywords
4-Dihydroxycinnamic acid derivatives , Cysteinyldopas , Pheomelanin , Thiol conjugation , 3
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1856985
Link To Document