Title of article
Organocatalytic asymmetric aza-Michael reaction: enantioselective addition of O-benzylhydroxylamine to chalcones
Author/Authors
Pettersen، نويسنده , , Daniel and Piana، نويسنده , , Francesca and Bernardi، نويسنده , , Luca and Fini، نويسنده , , Francesco and Fochi، نويسنده , , Mariafrancesca and Sgarzani، نويسنده , , Valentina and Ricci، نويسنده , , Alfredo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
7805
To page
7808
Abstract
A novel organocatalytic approach for aza-Michael reaction of chalcones using commercial and non-expensive O-benzylhydroxylamine and a readily available organocatalyst is provided. The use of this simple protocol results in β-keto hydroxylamines in up to 60% ee, thus extending the generality of the catalytic enantioselective aza-Michael reaction.
Keywords
Aza-Michael , organocatalysis , Chalcones , O-benzylhydroxylamine , Cinchona alkaloids
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1857072
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