Author/Authors :
Tatsuta، نويسنده , , Kuniaki and Suzuki، نويسنده , , Yoshikazu and Toriumi، نويسنده , , Tatsuya and Furuya، نويسنده , , Yoshiaki and Hosokawa، نويسنده , , Seijiro، نويسنده ,
Abstract :
The first total synthesis and structural determination of (+)-BE-52440A have been achieved by enantiodivergent synthesis. S-Bridging dimerization including SN2 epoxy-opening reaction of tetrasubstituted epoxide 2 with sodium sulfide has been achieved in excellent yield with high regioselectivity. The structure of (+)-BE-52440A was determined to be the dimer of kalafungin type pyranonaphthoquinone.
Keywords :
total synthesis , enantiodivergent synthesis , Tetrasubstituted epoxide , dimerization , BE-52440A
