Title of article :
Combinatorial synthesis of 4-oxo-4H-imidazo[1,5-a]quinoxalines and 4-oxo-4H-pyrazolo[1,5-a]quinoxalines
Author/Authors :
Spatz، نويسنده , , Julia H. and Umkehrer، نويسنده , , Michael and Kalinski، نويسنده , , Cédric and Ross، نويسنده , , Günther and Burdack، نويسنده , , Christoph and Kolb، نويسنده , , Jürgen and Bach، نويسنده , , Thorsten، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2007
Abstract :
A combinatorial synthetic route yielding imidazo[1,5-a]quinoxalines and pyrazolo[1,5-a]quinoxalines is described. The use of 2-fluoroaniline and 1H-imidazole-4-carboxylic acid, respectively, 1H-pyrazole-3-carboxylic acid in the Ugi-reaction (U-4CR) followed by a nucleophilic aromatic substitution (SNAr) affords the imidazo- as well as the pyrazolo-[1,5-a]quinoxaline moiety in good yield and high diversity.
Keywords :
Multi-component reaction , Ugi-reaction , nucleophilic aromatic substitution , Imidazo-quinoxaline , Pyrazolo-quinoxaline
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
