Author/Authors :
Zhang، نويسنده , , Pingsheng and Cedilote، نويسنده , , Miall and Cleary، نويسنده , , Thomas P. and Pierce، نويسنده , , Michael E.، نويسنده ,
Abstract :
Aromatic compounds bearing a basic nitrogen atom can be converted to the corresponding nitric acid salts. Mono-nitration of the compounds can be carried out by adding a dichloromethane solution of the salts to sulfuric acid, or by adding acetyl chloride (or trifluoroacetic anhydride) to a dichloromethane solution of the salts. This protocol provides, among other benefits, the most convenient and reliable way for the prevention of over-/under-nitration and is especially suitable for scale-up.
