β-Cyclodextrin as an efficient catalyst for the one-pot synthesis of 1-aminophosphonic esters in water

A simple, efficient, and general method has been developed for the one-pot synthesis of α-aminophosphonic esters in water using β-cyclodextrin as an efficient catalyst. α-Aminophosphonic esters were obtained in good yields (45–82%) and purity under mild conditions by the reaction of diethyl phosphite with a mixture of aldehyde and amine in water at reflux.