Title of article
Stereocalpin A, a bioactive cyclic depsipeptide from the Antarctic lichen Stereocaulon alpinum
Author/Authors
Seo، نويسنده , , Changon and Yim، نويسنده , , Joung Han and Lee، نويسنده , , Hong Kum and Park، نويسنده , , Seong Min and Sohn، نويسنده , , Jae-Hak and Oh، نويسنده , , Hyuncheol، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
3
From page
29
To page
31
Abstract
A new cyclic depsipeptide stereocalpin A (1) has been isolated from the MeOH extract of the Antarctic lichen Stereocaulon alpinum by various chromatographic methods. The structure of stereocalpin A (1) was mainly determined by analysis of the NMR spectroscopic data and by chemical methods. Stereocalpin A (1) is a unique cyclic peptide incorporating an unprecedented 5-hydroxy-2,4-dimethyl-3-oxo-octanoic acid in the structure. Stereocalpin A (1) shows moderate cytotoxicity against three human solid tumor cell lines.
Keywords
Stereocalpin A , Stereocaulon alpinum , cytotoxicity , Cyclic depsipeptide
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1857625
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