Title of article
A chemoselective aniline–chloropyrimidine coupling in a competing electrophilic environment
Author/Authors
Choudhury، نويسنده , , Anusuya and Chen، نويسنده , , Hongfeng and Nilsen، نويسنده , , Christopher N. and Sorgi، نويسنده , , Kirk L.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
102
To page
105
Abstract
A highly chemoselective substitution on 4-amino-6-chloropyrimidine ring system having a competing aldehyde functionality has been realized with anilines which produces 4, 6-diaminopyrimidine-5-carbaldehyde in high yield. The reaction may involve the intermediacy of imines. A variety of aromatic amines participate in this reaction successfully to generate diaminopyrimidine aldehydes in moderate to high yield.
Keywords
Acid catalyzed coupling , Chloropyrimidine , Diaminopyrimidines
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1857643
Link To Document