Neurohormonal responses during positive pressure mechanical ventilation

Positive pressure mechanical ventilation is used daily in critical care units to support ventilation and improve oxygenation in critically ill patients. One adverse response to positive pressure mechanical ventilation is a reduction in urinary output and sodium and water retention. This consequence is attributed to complex neurohormonal responses intended to maintain hemodynamic homeostasis. This article reviews the physiologic nature of these responses and research findings related to these responses and provides clinicians with information about the importance of these responses, particularly in patients with underlying cardiac dysfunction. (Heart Lung® 1999;28:149-65)