Microwave-assisted synthesis of a triazole-linked 3′–5′ dithymidine using click chemistry

Synthesis of a triazole-linked 3′–5′ thymidine dimer making use of 1,3-dipolar cycloaddition is described. The azido-precursor was obtained by regioselective chlorination of thymidine, followed by azidation. The second precursor, a propargyl derivative, was obtained by selective 3′-O-alkylation of thymidine. Two ‘click systems’ were compared to obtain the desired dimer. These reactions were performed by microwave irradiation.