Title of article
A new synthetic route to 3-polyfluoroalkyl-containing pyrroles
Author/Authors
Roman V. and Shaitanova، نويسنده , , Elena N. and Gerus، نويسنده , , Igor I. and Kukhar، نويسنده , , Valery P.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
1184
To page
1187
Abstract
A novel approach to 3-polyfluoroalkyl pyrroles is reported based on step by step reactions: 1,2-addition of Me3SiCN to β-alkoxyvinyl polyfluoroalkyl ketones, reduction with LiAlH4 and subsequent hydrolysis with intramolecular cyclization. The hydrolytic instability of various polyfluoroalkyl groups at position 3 of the pyrrole ring was evident and a pathway for the hydrolysis was proposed.
Keywords
enone , pyrrole , cyclization , Hydrolysis , Fluoroalkyl groups , 3-Polyfluoroalkyl pyrroles
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1858216
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