A novel three-component reaction for the synthesis of 1,2-dihydroisoquinolines via the reaction of isoquinoline and isocyanides with strong CH-acids in water

A straightforward and efficient method for the synthesis of 1,2-dihydroisoquinolines via the one-pot, three-component reaction of an isocyanide, isoquinoline and a strong CH-acid in water without using any catalyst at 70 °C is reported. The method offers several advantages including high yields of products and an easy work-up procedure.