Title of article :
First total synthesis of sterenins A, C and D
Author/Authors :
Shinozuka، نويسنده , , Tsuyoshi and Yamamoto، نويسنده , , Yuko and Hasegawa، نويسنده , , Toru and Saito، نويسنده , , Keiji and Naito، نويسنده , , Satoru، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
The first total synthesis of sterenins A, C and D, potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), is described. The prenyl group was regioselectively introduced by a Claisen rearrangement, whereas the construction of an isoindolinone skeleton was accomplished by the lactamization of lactones assisted by a phenolic hydroxyl group.
Keywords :
11b-HSDs , Sterenin , Isoindolinone , Claisen rearrangement , Metabolic Diseases
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
