Title of article
Tf-based sulfamide-amine alcohol-catalyzed enantioselective alkynylation of aldehydes
Author/Authors
Li، نويسنده , , Hongwang and Huang، نويسنده , , Yongbo and Jin، نويسنده , , Wei and Xue، نويسنده , , Feng and Wan، نويسنده , , Boshun، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
1686
To page
1689
Abstract
A series of new chiral Tf-based sulfamide-amine alcohols (Tf-based SAA) were synthesized from natural chiral (−)-ephedrine and aziridines derived from commercially available chiral amino alcohols. Among these ligands, 3a was found to be more effective for the addition reaction of alkynylzinc to aromatic aldehyes at room temperature without using other kinds of metal species, providing 81–92% ee and up to 99% yields.
Keywords
Sulfamide-amine alcohols , asymmetric addition , Propargylic alcohols , Alkynylation , Aldehydes
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1858474
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