Title of article :
Hydrazine sulphate: a cheap and efficient catalyst for the regioselective ring-opening of epoxides. A metal-free procedure for the preparation of β-alkoxy alcohols
Author/Authors :
Leitمo، نويسنده , , Alcino J.L. and Salvador، نويسنده , , Jorge A.R. and Pinto، نويسنده , , Rui M.A. and Sل e Melo، نويسنده , , M. Luيsa، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
An efficient and general procedure for the regioselective ring opening of epoxides with alcohols to afford the corresponding β-alkoxy alcohols, using hydrazine sulphate as catalyst, is described. This new metal-free process was found to be highly versatile allowing the use of primary, secondary and tertiary alcohols as nucleophiles and a large variety of epoxides, including 5α,6α-, 5β,6β- and 2α,3α-epoxysteroids, as substrates.
Keywords :
Hydrazine sulphate , Metal-free catalysis , epoxides , ?-Alkoxy alcohols , Steroids
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters