Title of article
Organocatalytic highly enantioselective tandem Michael–Knoevenagel reaction for the synthesis of substituted thiochromanes
Author/Authors
Dodda، نويسنده , , Rajasekhar and Mandal، نويسنده , , Tanmay and Zhao، نويسنده , , Cong-Gui، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
1899
To page
1902
Abstract
Enantioenriched tetrasubstituted thiochromanes have been synthesized using a tandem Michael addition–Knoevenagel reaction between 2-mercaptobenzaldehydes and benzylidenemalonates with a 9-epi-aminoquinine thiourea derivative as the catalyst. Steric and electron effects were found to affect profoundly the enantioselectivity and diastereoselectivity of the reaction.
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1858575
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