Author/Authors :
Yu، نويسنده , , Hannah and Richey، نويسنده , , Rachel N. and Mendiola، نويسنده , , Javier and Adeva، نويسنده , , Marta and Somoza، نويسنده , , Carmen and May، نويسنده , , Scott A. and Carson، نويسنده , , Matthew W. and Coghlan، نويسنده , , Michael J.، نويسنده ,
Abstract :
A stereoselective method for the preparation of dibenzoxapine containing tetrasubstituted exocyclic E-alkenes has been developed. The key reaction involves an intramolecular cyclocarbopalladation of alkynes to form a vinylpalladium species and subsequently coupling the vinylpalladium with methylboronic acid. The approach provides a straightforward method for the synthesis of tetrasubstituted exocyclic E-alkenes.
