Author/Authors :
Gemma، نويسنده , , Sandra and Kukreja، نويسنده , , Gagan and Tripaldi، نويسنده , , Pierangela and Altarelli، نويسنده , , Maria and Bernetti، نويسنده , , Matteo and Franceschini، نويسنده , , Silvia and Savini، نويسنده , , Luisa and Campiani، نويسنده , , Giuseppe and Fattorusso، نويسنده , , Caterina and Butini، نويسنده , , Stefania، نويسنده ,
Abstract :
Nickel(II) chloride/sodium borohydride combination was employed for the reduction of 4-hydrazinoquinoline derivatives to the corresponding anilines. This reductive protocol was efficiently applied for the reductive cleavage of monosubstituted hydrazines. We described herein the microwave-assisted synthesis of 4-hydrazinoquinolines, which furnished a high yielding and rapid two-step procedure for the synthesis, under mild conditions, of 4-aminoquinolines as antimalarial precursors.
Keywords :
Hydrazines , 4-Aminoquinolines , nickel boride , Reduction , microwave
