Title of article
Diazonamides C–E, new cytotoxic metabolites from the ascidian Diazona sp.
Author/Authors
Fernلndez، نويسنده , , Rogelio and Martيn، نويسنده , , Marيa Jesْs and Rodrيguez-Acebes، نويسنده , , Raquel and Reyes، نويسنده , , Fernando and Francesch، نويسنده , , Andrés and Cuevas، نويسنده , , Carmen، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
3
From page
2283
To page
2285
Abstract
Three new macrocyclic peptides, diazonamides C–E (1–3), were isolated together with the previously reported diazonamides A (4) and B (5) from samples of the marine ascidian Diazona sp. collected in Indonesia. Their structures were assigned on the basis of detailed analysis of the 1D and 2D NMR and mass spectral data as well as Marfey’s analysis of the aminoacid residues. All the new compounds isolated displayed moderate cytotoxicity against a panel of three human tumor cell lines.
Keywords
Marine tunicate , diazonamide , NMR , cytotoxicity
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1858783
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