Author/Authors :
Fernلndez، نويسنده , , Rogelio and Martيn، نويسنده , , Marيa Jesْs and Rodrيguez-Acebes، نويسنده , , Raquel and Reyes، نويسنده , , Fernando and Francesch، نويسنده , , Andrés and Cuevas، نويسنده , , Carmen، نويسنده ,
Abstract :
Three new macrocyclic peptides, diazonamides C–E (1–3), were isolated together with the previously reported diazonamides A (4) and B (5) from samples of the marine ascidian Diazona sp. collected in Indonesia. Their structures were assigned on the basis of detailed analysis of the 1D and 2D NMR and mass spectral data as well as Marfey’s analysis of the aminoacid residues. All the new compounds isolated displayed moderate cytotoxicity against a panel of three human tumor cell lines.
Keywords :
Marine tunicate , diazonamide , NMR , cytotoxicity
