Title of article :
(−)-Quinic acid: a versatile precursor for the synthesis of analogues of 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC) which possess anti-tumour properties
Author/Authors :
Arthurs، نويسنده , , Claire L. and Lingley، نويسنده , , Katharine F. and Piacenti، نويسنده , , Michela and Stratford، نويسنده , , Ian J. and Tatic، نويسنده , , Tanja and Whitehead، نويسنده , , Roger C. and Wind، نويسنده , , Natasha S.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
Syntheses of three novel analogues of the Streptomyces metabolite COTC are described, using the versatile chiral pool starting material, (−)-quinic acid. The results of bioassays of the target compounds against two lung cancer cell lines, A549 and H460, are presented.
Keywords :
Cyclopropane , anti-cancer , Quinic acid , natural product
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
