Author/Authors :
Gomez، نويسنده , , Laurent and Gellibert، نويسنده , , Françoise and Wagner، نويسنده , , Alain and Mioskowski، نويسنده , , Charles، نويسنده ,
Abstract :
A novel solid-phase synthesis of tetrasubstituted 2-imino-1,3-thiazolines using a functionalizing cleavage strategy is described. The synthetic route utilized the ambident reactivity of a dithiocarbamate functionality to synthesize the key resin-bound electrophilic thiazolium intermediate. The desired products were efficiently obtained in high purity by the reaction of various amines with the thiazolium salt.
