A facile synthesis of 2-(N-alkylamino)-pyrimidin-4-one derivatives
Author/Authors :
Li، نويسنده , , Jizhen and Kou، نويسنده , , Jingping and Luo، نويسنده , , Xuyang and Fan، نويسنده , , Erkang، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Pages :
3
From page :
2761
To page :
2763
Abstract :
Substituted 2-(N-alkylamino)-pyrimidin-4-ones were synthesized from N-alkyl β-amino acid esters starting with guanidinylation using Pbf-activated thiourea. The six-membered pyrimidinones were obtained in good yields via intramolecular cyclization during TFA cleavage of the Pbf protecting group.
