Author/Authors :
Brunet، نويسنده , , Ernesto and Parra، نويسنده , , Francisco and Mantecَn، نويسنده , , Susana and Juanes، نويسنده , , Olga and Rodrيguez-Ubis، نويسنده , , Juan Carlos and Cruzado، نويسنده , , Ma Carmen and Asensio، نويسنده , , Ramَn، نويسنده ,
Abstract :
The straightforward synthesis of the novel 9-tritylhydrazone erythromycin A and its highly regioselective O-methylation at C(6)–OH are described. Preliminary conformational data based on X-ray diffraction, 1H NMR and molecular mechanics is also presented with the aim of understanding the observed high regioselectivity. The facile synthesis of 6,12-O-dimethylerythromycin A, a standard to assess clarithromycin purity in quality control processes, is reported as well.
Keywords :
Erythromycin , Clarithromycin , conformational analysis , Regioselective methylation
